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    您现在的位置: 论文网 >> 医药学论文 >> 临床医学论文 >> 探讨糖尿病周围神经病变应用不同药物治疗临床效果论文

    探讨糖尿病周围神经病变应用不同药物治疗临床效果

    出处:论文网
    时间:2019-09-11

    探讨糖尿病周围神经病变应用不同药物治疗临床效果

      【中图分类号】R587.2 【文献标识码】A 【文章编号】1005-0019(2019)15--02

      糖尿病是由于患者胰島素分泌不足、分泌缺陷或胰岛素功能障碍引起的代谢性疾病,主要表现为高血糖,但是持续高血糖和长期功能紊乱可引起全身组织器官病变及神经系统损伤,甚至引起器官衰竭,严重影响患者生存质量[1-2]。目前临床上治疗糖尿病周围神经病变以药物治疗为主,常用的药物有磺酰脲类、双胍类、α-葡萄糖苷酶抑制剂等,但是不同药物治疗效果不同,该院2016年1月—2017年1月应用不同药物的方法进行治疗,取得较好的效果,现报道如下。

      1 资料与方法

      1.1 一般资料 方便选取在该院糖尿病周围神经病变患者118例,随机分为对照组与观察组,每组59例。其中对照组患者中男21例,女38例,年龄47~75岁,平均年龄61岁;观察组患者中男22例,女37例,年龄45~73岁,平均年龄59岁。两组患者在性别、年龄、血糖、病程等资料差异无统计学意义(P>0.05),具有可比性。

      1.2 诊断标准 ①患者空腹血糖>6.1 mmoL/L,餐后2 h血糖>7.8 mmoL/L;②患者在诊断中有手足麻木、疼痛、腹胀等症状;③温度觉异常、足部感觉减退或消失、震动觉异常、踝反射消失、神经传导有一定障碍,有2项及以上者。

      1.3 治疗方法 观察组:采用生理盐水加300 g硫酸锌(国药准字H11021286)治疗,静脉滴注,1次/d,治疗1个月为1个疗程;对照组:采用生理盐水和甲钴胺(1.5 g,国药准字H20052207x)进行治疗,静脉滴注,1次/d,治疗1个月为1个疗程。完成治疗后对比两组患者的治疗效果。

      1.4 评判标准 治疗结果按照患者临床情况分为显效、好转和无效。

      显效:患者临床症状,包括腹胀、疼痛、麻木等情况大有好转,神经传导速度增快;好转:患者临床症状,包括腹胀、疼痛、麻木等情况有所有好转;无效:患者症状无改善,甚至加重。总有效率=显效+好转。

      1.5 统计方法 采用SPSS 17.0统计软件处理数据,计量资料用()表示,采用t检验,计数资料[n(%)]采用χ2检验,P<0.05为差异有统计学意义。

      2 结果

      2.1 治疗结果 经统计分析得出,对照组总有效率为57.62%,观察组总有效率为94.75%,经统计学分析,差异有统计学意义(P<0.05)。

      2.2 生理功能检查结果 两组患者在不同药物治疗后,观察组患者生理功能明显好于对照组,差异有统计学意義(P<0.05)。

      3 讨论

      糖尿病患者主要以多尿、多饮、多食和消瘦为主要症状,长期糖尿病患者大多数会有慢性并发症,主要有糖尿病视网膜病变、糖尿病性肾病及糖尿病神经病变等。糖尿病是由于患者胰岛素分泌不足、分泌缺陷或胰岛素功能障碍引起的代谢性疾病,主要表现为高血糖,但是持续高血糖和长期功能紊乱可引起全身组织器官病变及神经系统损伤,甚至引起器官衰竭,严重影响患者生存质量。糖尿病周围神经病变指糖尿病患者由于代谢紊乱、细胞因子异常、血管损伤等病因出现与周围神经功能障碍相关的症状,如四肢麻木、便秘、腹胀、疼痛等。糖尿病周围神经病变是糖尿病患者常见的并发症之一,患者出现不同程度的神经病症反应,为患者带来巨大的疼痛与不便。目前临床上治疗糖尿病周围神经病变以药物治疗为主,常用的药物有磺酰脲类(格列齐特、格列吡嗪)、双胍类(二甲双胍)、α-葡萄糖苷酶抑制剂(阿卡波糖)等,但是治疗确达不到理想效果。硫酸锌片常用于由于锌缺乏引起的贫血、食欲缺乏、营养性侏儒、生长发育迟缓及肠病性肢端皮炎,也可用于类风湿性关节炎、间歇性跛行、异食癖、肝豆状核变性、慢性溃疡、痤疮、结膜炎、口疮等的辅助治疗。该文选用硫酸锌治疗糖尿病周围神经病变疾病,观察其治疗作用。

      该文采用不同药物治疗糖尿病周围神经病变,对照组采用生理盐水配合甲钴胺治疗,观察组采用硫酸锌进行治疗,观察两组患者的治疗情况及患者生理功能等情况。结果对照组总有效率为57.62%,观察组总有效率为94.75%,同时观察组患者生理功能明显好于对照组,与谢红武[3]的研究中,对照组患者总有效率为64.4%,治疗组患者总有效率为95.56%,治疗组总有效率明显高于对照组结果相符。

      因此,采用硫酸锌进行治疗糖尿病周围神经病变,效果明确,不良反应小,操作简单,不但减轻患者身体上的折磨,还可以减轻患者精神上的痛苦,減轻患者家属的负担,缓和了医患关系,增加了患者对抗疾病的自信心,提高患者生活质量,减少并发症的发生,改善患者不良心理,具有临床应用价值。

    探讨糖尿病周围神经病变应用不同药物治疗临床效果

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